|
KMID : 0613820050150040595
|
|
Journal of Life Science
2005 Volume.15 No. 4 p.595 ~ p.599
|
|
|
Inhibitory Effect of Radish on Gastric Cell Toxicity and Interleukin-8 Production Induced by Helicobacter pylori
|
|
Shon Yun-Hee
Suh Jeong-Ill
Park In-Kyung
Hwang Cher-Won
Kim Chul-Ho
Nam Kyung-Soo
|
|
|
Abstract
|
|
|
|
The effects of Korean and Japanese radishes on the viability and interleukin (IL)-8 production by Helicobacter pylori were investigated in human gastric epithelial cell. Cell viability was significantly decreased when they were incubated with H. pylori toxin (p＜0.05, p＜0.01 and p＜0.005). Co-incubation with Korean or Japanese radish increased H. pylori toxin-inhibited cell growth in a concentration-dependent manner. The production of IL-8 was greatly increased in H. pyloriinfected gastric epithelial cell in concentration- and time-dependent manners. The increased production of IL-8 was significantly inhibited by Korean (p＜0.05 and p＜0.01) or Japanese (p＜0.05) radishes (5～10 ㎎/ml). These results indicate that Korean and Japanese radishes have protective effects on H. pylori-inhibited cell growth and H. pylori-induced gastric mucosal cell inflammation by suppressing the production of inflammatory cytokine (IL-8) from gastric epithelial cell.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|